30B Parameters
Large-scale biological foundation model
The award-winning
multi-modal foundation
model for biomanufacturing
From DNA sequence to commercial-scale manufacturing. Canopy is twig bio’s graph-native foundation AI model for engineering biology, designed to predict how microbes will perform before they are ever built.
By reasoning across biological sequences, metabolic pathways, host organisms, fermentation conditions and proprietary experimental data, Canopy enables faster, more reliable development of industrial bioprocesses.
Transform your biomanufacturing with Canopy AI
532 Species
Trained across diverse organisms
15M Designs Evaluated
Per programme on average
12K+ Strains Generated
across industrial programmes
5 Programmes
Spanning distinct product classes
Multi-modal Biological Foundation Model
- Proteins
- Pathways
- Microbes
- Manufacturing
Cross scale reasoning and biological design From biological complexity to manufacturing outcomes
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Protein Sequences
Amino acid sequences and structures
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Biochemical Networks
Pathways and molecular interactions
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Metagenomics
Microbial diversity from environments
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Multi-Omics
Genomics, transcriptomics, proteomics, metabolomics
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Experimental Data
High-throughput assays and process data
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Novel Enzymes
Discover and design enzymes with novel functions
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Pathway Designs
Design and optimize pathways to target molecules
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Strain Engineering
Engineer robust microbial cell factories
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Performance Prediction
Protect yield, titer and productivity across conditions
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Manufacturing Insights
Generate actionable insights for scale-up/process control
Applications
Canopy is designed for industrial biotechnology teams developing products across a broad range of sectors with validated results to back it up.
Specialty
Chemicals
Cosmetic
Actives
Sustainable
Feedstocks
Flavours &
Fragrances
Novel
Enzymes
Industrial
Biocatalysts
Pharma
Intermediates
Bio-Based
Materials
Do these challenges sound familiar?
Traditional Design-Build-Test-Learn workflows are slow, expensive and highly iterative. Scientists spend months screening thousands of variants before discovering bottlenecks, resulting in excessive cost, long timelines and significant technical risk.
Unknown Enzymes
Metabolic Burden
Toxic Intermediates
Poor Expression Balance
Low Fermentation Titres
Poor Scale-Up Performance
Canopy supports the complete strain engineering workflow and feeds every prediction back into a closed Design-Build-Test-Learn cycle.
Novel Enzyme Discovery
Design enzymes for reactions where no suitable catalyst exists.
Pathway Design
Generate biosynthetic pathways from central metabolism to target molecule.
Host Optimization
Rank knockouts, overexpression strategies and CRISPR edits for maximum production.
Fermentation Performance
Predict titre, productivity and process behaviour across manufacturing conditions.
Canopy: how it works
Independent benchmarking confirms strong predictive capability, underpinned by a foundation model trained at unprecedented biological scale.
Canopy combines four core capabilities into a single, unified platform that reasons across the full biological stack.
In-Silico Validation
Independent benchmarking confirms strong predictive capability, underpinned by a foundation model trained at unprecedented biological scale.
>0.8 R2
Titre Prediction — accurate forecasting of continuous fermentation performance across held-out datasets.
>0.80
Expression Classification — reliable identification of high-performing production strains before lab work.
Knockout Ranking
Successfully prioritises genetic interventions before laboratory validation, reducing experimental cost.
Gene Order Prediction
Differentiates construct architectures using whole-plasmid sequence representations.
In-Vitro Validation
Independent benchmarking confirms strong predictive capability, underpinned by a foundation model trained at unprecedented biological scale
Canopy, powered by Sovereign AI
CANOPY is being developed with support from the UK Sovereign AI programme, helping establish strategic national capability in AI for engineering biology and biomanufacturing.
Our AI partners
