Isoprene

bio:drive - intelligent microbe design

Here’s what bio:drive says about Isoprene:

• Viable pathways recommended / (generated) 2 / (54) i
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  Using our retrosynthesis algorithms, the number of viable biochemical routes generated and recommended to the target ingredient.

• Median pathway length 6 biochemical reactions i
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  Of the viable pathways recommended, the median number of biochemical reactions.

• Max free energy change -27.9 KJ.mol-1 i
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  For the most efficient pathway, the Gibbs free energy change.

• Max theoretical yield 82.1 % i
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  For the most efficient pathway, the maximum possible conversion of feedstock to the target ingredient based on reaction efficiency.

• Predicted pathway bottlenecks 4 reactions i
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  For the most efficient pathway, the number of biochemical reactions predicted to be limiting.

• Enzyme variants recommended / (generated) 20 / (7,891) i
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  For the pathway bottlenecks identified, the enzyme variants generated and recommended using our enzyme generation engine.

• Predicted enzyme reactivity improvement 4.1x i
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  With the enzyme variants recommended, the predicted improvement in performance.

• Predicted host microbe bottlenecks 4 genetic edits i
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  Number of recommended genetic edits to improve pathway flux to target ingredient.

• Predicted host microbe flux improvement 7x i
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  With the host microbe genetic edits, the predicted improvement in performance.

• Continuous fermentation enabled i
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  Whether strains can be built for industrial scale and continuous fermentation systems using our in-house stabilisation system.

• Number of microbe versions designed for grow:bot build 20,736,000,720 i
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  Diversity potential from pathway, enzyme and host microbe edits.

• Overall potential improvement with bio:drive 14x i
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  Potential improvement in yield vs. traditional methods.